Experiment study on the safety of selective COX-2 inhibitor-celecoxib on gastric mucosa / 中华消化杂志

ABSTRACT

Objective To compare the gastric mucosa damage induced by celecoxib and conventional NSAIDs——indomethacin. Methods NSAIDs induced gastric mucosal damage model in rats was obtained by pouring indomethacin, celecoxib respectively (n=8); After gastric damage induced by means of 100% ethanol, celecoxib were administered by gastric gavage (n=8). Gastric mucosal 6-keto-PGF 1? ,TXB 2 level and lesion index (LI) were measured. Morphological changes of gastric mucosa were assessed under light and scanning electronic microscopy. Results Indomethacin caused obvious gastric damage (LI13.38?2.06) and a marked reduction of 6-keto-PGF 1? ,TXB 2 level was observed (P