Experimental study of the mechanism in esophageal restenosis after balloon dilation of benign stricture / 介入放射学杂志

ABSTRACT

Objective Experimental study of the mechanism in esophageal restenosis after balloon dilation of benign stricture.Methods Esophageal stenosis model of the rats was created by 5ml of 50% NaOH solution burn with double balloon method, and esophageal restenosis (RS) model was developed by esophageal stenosis with dilation of PTCA balloon catheter. Quantitative and quanlitative analysis of esophageal stenosis and RS formation in the rats were observed and recorded by analytic measurements imaging and immunohistologic chemistry respectively. Results Esophageal benign stricture and RS model of 49 rats were developed. Cross section area and perimeter of esophageal mucosa layer, muscule layer and the whole layer had increased in experimental group. Comparing to control group, it had remarkable significance in statistics ( P