Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis
Annals of Surgical Treatment and Research
;
: 1-8, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-57055
ABSTRACT
The shaping of new blood vessels is a significant event in cancer growth and metastasis. Therefore, the molecular system of cancer angiogenesis has garnered considerable interest in cancer research. The vascular endothelial growth factor (VEGF) and VEGF receptor pathway are recognized as the key regulators of the angiogenic process. Activation of the VEGF/VEGF-receptor pathway initiates signaling cascades that promote endothelial cell growth, migration, and differentiation. Recently, VEGF was shown to play a role in the recruitment of bone marrow-derived endothelial progenitor cells to neovascularization sites. The role of VEGF in promoting tumor angiogenesis and the occurrence of human cancers has led to the rational design and development of agents that selectively target this pathway. Moreover, these anti-VEGF/VEGF receptor agents show therapeutic potential by inhibition of angiogenesis and tumor growth in preclinical models. In this review, we summarize the role of the VEGF pathway during tumor angiogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
Vasos Sanguíneos
/
Hipóxia Celular
/
Inibidores da Angiogênese
/
Receptores de Fatores de Crescimento do Endotélio Vascular
/
Células Endoteliais
/
Fator A de Crescimento do Endotélio Vascular
/
Microambiente Tumoral
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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