Effects of mild hypothermia on heart of rats with focal brain ischemia / 中华物理医学与康复杂志

ABSTRACT

Objective To investigate the effects of systemic mild hypothermia on heart. Methods Fifty-eight Wistar rats were divided randomly into three groups control group (n=10), normal thermic group (n=24) and mild hypothermic group (n=24). After the model of middle cerebral artery occlusion (MCAO) was made, electrocardiograph (ECG) was used to monitor the cardiac function of the animals. The changes of myocardial high-energy phosphates (ATP,ADP,AMP) and energy charge (EC) were evaluated after 12 hours of ischemia, and the myocardial ultrastructure observed. Results Compared with the control group, the ATP, ADP and EC in the normal thermic group and mild hypothermic group were lower after 12 hours of ischemia (P