Antitumor Activity of Zhongjiefeng Injection on FC in Mice with Precarcinoma of Stomach and Its Toxicity / 中药新药与临床药理

ABSTRACT

Objective To Study the antitumor activity of Zhongjiefeng injection(ZJF)on FC in mice with precancer of stomach and its toxicity.Methods The model mice transplanted with pre cancer of stomach was established an d the effects of ZJF on inhibitory rate,body weigh t,thymus index and spleen index,whi te blood cell(WBC)count and FC cell strain in model mice were observed.Results ZJF had an obvious antitumor effect.The inhibitory rates of ZJF ip 0.2g /k g,1g /kg and 2g /kg were 39.83%,64.41%and 53.39%respectively.ZJF increased the indexes of spleen and thymus,the amount of WBC and body weight.The inhibitory rates of ZJF ip 100mg /mL,50mg /mL,25mg /mL,12.5mg /mL and6.25mg /mL were 65%,63%,57%,55%and44%respectively.Conclusion ZJF exerts an in -vitro and in -vivo antitumor effect for precancer of stomach in mice and increase the indexes of immune organs and amount of WBC.