Experimental studies on blood-activating and stasis-eliminating actions of Danshensu Capsules / 中成药

ABSTRACT

Objective: To investigate the effect of Danshensu Capsules on platelet aggregation, experimental thrombosis and hemorrheology in rat. Methods: The effects of Danshensu Capsules were observed on platelet aggregation induced by ADP. Occlusive thrombotic time was determined by electrostimulating; “blood stasis” model was prepared by ice water stimulation and the main hemorheological indexes were detected. Results: Danshensu Capsules could greatly inhibit the platelet aggregation in rat induced by ADP and delay occlusive thrombosis time after electrostimulating rat common carotid artery as well as decrease whole blood viscosity, plasma viscosity, red-cell specific volume, red-cell electrophoresis time, yield stress and red-cell aggregation indexes in experimental rat with the blood stasis syndrone. The rat's hemorheological properties were improved. Conclusion: Danshensu Capsules could decrease obviously the blood state with “dense、viscosity、aggregation、coagulation” and have obvious actions of blood-activating and stasis-eliminating.