Expression of PTEN,CDK4 protein in endometrial carcinoma and its clinical significance / 重庆医科大学学报

ABSTRACT

Objective:To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogenisis,progression and recurrence of endometrial carcinoma.Methods:A specific and sensitive immunohistochemical S-P assay was used to detect the expression of PTEN and CDK4 in paraffin-embedded sections of 50 cases of endometrial carcinoma,12 atypical hyperplasia of endometrium and 10 normal endometrium.Results:1.The positive immunostainning rates of PTEN in endometrial carcinoma,atypical hyperplasia of endometrium and normal endometrium were 56.00%,91.00%,100.00%,respectively;and the difference was statistically significant between carcinoma and normal endometrium or atypical hyperplasia of endometrium(P1/2 muscle invasion cancer and in recurrence cases.Conclusion:The results suggest that the aberrant expressions of PTEN and CDK4 are closely related to the occurrence,development and recurrence of endometrial carcinoma.