Study on the expression of PPARs and NF?B in endothciial cells of hyperlipidemic rats / 重庆医科大学学报

ABSTRACT

Objective: To investigate the expression of PPAR?, PPAR? and NF?B in the aortic endothelial cells of the normal and hyperlipidemic rats and the change of IL-6 with the treatment of fibrates in vivo.Methods:The hyperlipidemic rat was established by feeding the high cholesterol food.The expressions of PPAR?,PPAR?,NF?B and IL-6 in endothelial cells located in the aorta were presented by immunohistochemistry.The alteration among the PPAR?,PPAR? and IL-6 in the hyperlipidemic rat with the treatment of gemfibrate and bezafibrate was observed.Results:There was a weak expression of PPAR?,PPAR?,NF?B and IL-6 in the normal rat aorta endothelial cells,which were all enhanced in the hyperlipidemic rat.NF?B was drastically presented.After the treatment of gemfibrate and bezafibrate the expression of PPAR? increased,while that of IL-6 decreased relatively,but NF?B expression was not directly influenced.Conclusion:The expressions of PPARs and NF?B increased in hyperlipidemic rats.Fibrates may relieve the secretion of inflammation factors in vivo to some degree through the activation of PPARs.