Acute lung injury induced by endotoxic shock and imbalance of Th1/Th2 type of cytokines / 重庆医科大学学报

ABSTRACT

Objective:To investigate the type of imbalance of cytokines and its relations to the ALI induced by endotoxic shock.Methods:ALI rats model was made by injcting lipopolysacharide(LPS) into jugular vein.Enzyme-linked immunosorbent assay(ELISA) was employed to measure interferon-?(IFN-?) level,interleukin-4(IL-4) level and the ratio of IFN-?/IL-4.Pathological examination was made under optical microscope at the same time.Results:Compared with normal control group,the IFN-? level,the ratio of IFN-?/IL-4 increased significantly(P0.05).Pathological examination of lung tissue proved the presence of ALI in rats.Conclusion:The imbalance of Th1/Th2 type cytokines exists in the endotoxic shock-induced ALI.