Solvent extraction of berberine hydrochloride and palmatine hydrochloride in Cortex Phellodendri / 中成药

ABSTRACT

AIM: To establish an extraction of alkaloid from Cortex Phellodendri METHODS: Taking berberine hydrochloride and palmatine hydrochloride in Cortex Phellodendri as evaluating index determined by the HPLC,the effects of different solvents,extraction time,and extraction models on extraction rate of the berberine hydrochloride and palmatine hydrochloride were systematically investigated. Berberine hydrochloride and palmatine hydrochloride in Cortex Phellodendri from different sources were also involved. RESULTS: The ultrasound extraction with hydrochloric acid-methanol (1∶100) up to 20min was more effective. CONCLUSION: The kinds of solvent and models of extraction have a great influence upon the extracting efficiency of berberine hydrochloride and plamatine hydrochloride.