Study on preparation and in vitro release characteristics of Bitongning Patch / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Article
em Zh
| WPRIM
| ID: wpr-572265
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WPRO
ABSTRACT
AIM: To prepare Bitongning Patch(Flos Daturae, Moschus and Camphora, etc.) and study its in vitro release characteristics. METHODS: Bitongning Patch was prepared with high polymer hydrophilic material as matrix. The determination method of scopolamine was established by HPCE. The in vitro release was studied according to the requirement of Chinese Pharmacopoeia(2000) and the percutaneous absorption of Bitongning Patch was evaluated in use of the Franz diffusion cell. RESULTS: The release mechanism of Bitongning Patch in vitro coincided with Higuchi Equation. The release rate was 0.4698mg?cm -2?h -1/2. Scopolamine in Patch permeated in vitro at the speed of 0.067mg?cm -2?h -1 by zero-order kinetics. CONCLUSIONS: Bitongning Patch is a skeleton controlled TDDS whose permeation speed is limited by skin.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional Patent Medicine
Ano de publicação:
1992
Tipo de documento:
Article