Short-term Effect of Phyllanthus Compound and Lamivudine in Treating Chronic Hepatitis B: An Observation of 30 Cases / 广州中医药大学学报

ABSTRACT

[Objective] To investigate the therapeutic effect of Phyllanthus compound (PC, mainly composed of Herba Phyllanthus, Radix Astragali, Radix Notoginseng, Radix Glycyrrhizae, etc.) and lamivudine on chronic hepatitis B. [ Methods ] Sixty cases of chronic hepatitis B were randomized to two groups group A (the combination of PC and lamivudine) and group B (lamivudine 100mg/d). After a six-month treatment, the therapeutic effect was evaluated. [Results] After treatment, symptoms and signs were improved in group A. The recovery rate of alanine aminotransferase (ALT) was 83.3% and 53.3%, the rate of hepatitis B E antigen (HBeAg) turning negative was 73.3% and 13.3% , the percentage of HBeAg ( - ) or anti-HBe ( + ) was 53.3% and 6.7% and HBV-DNA-turning-negative rate was 93.3% and 70.0% in groups A and B respectively (P