Relationship Between Serum Leptin Level and Qi or Yang Deficiency Syndrome of Spleen and Kidney in Chronic Renal Failure / 广州中医药大学学报

ABSTRACT

[Objective] To investigate the relationship between serum leptin level in chronic renal failure (CRF) and Qi or yang deficiency syndrome of spleen and kidney. [Methods] Thirty-eight cases of CRF and 16 healthy subjects as control were enrolled in this study. The CRF patients were classified as Qi /yang deficiency syndrome of spleen and kidney (pattern 1) and non-Qi/yang-deficiency syndrome of spleen and kidney (pattern 2). Serum leptin level was detected by enzyme-linked immunosorbent assay and nutrient parameters such as serum albumin (ALB), C-reation protein (CRP) and pre;ilbumin (preAlb) levels were also observed. The relationship of leptin level and nutrient parameters with Qi or yang deficiency syndrome of spleen and kidney was observed. [Results] The serum leptin level of pattern 1 was higher than that of pattern 2 ( P 0.05) . [ Conclusion ] Serum leptin may be the partial material base of Qi or yang deficiency syndrome of spleen and kidney and this is worthy doing further research. The uncertain relationship between nutrient parameters and Qi or yang deficiency syndrome of spleen and kidney may be due to the increase of type Ⅱ error which results from the small sample size.