Danshen glucose injection protection against experimental myocardial ischemia of rats / 中成药

ABSTRACT

AIM: Two models of experimental myocardial ischemia were set up to observe the protection of Danshen glucose injection against ischemia in rats. METHODS: Models of experimental acute myocardial ischemia were made by ligature or medication (pituitrin) to check the indices of ECG, hemodynamics, and morphology. RESULTS: A dosage of Danshen glucose injection 4.0 g/kg, 8.0 g/kg was given to rats by intravenous injection; the rats had undergone a thirty-minute ligatute of coronary left anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Danshen glucose injection exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (?dp/dt max ), and ST segment (electrocardiogram). The injection markedly reduced the myocardial infarct size of the coronary-ligatured rats. The injection benefited the rats with pituitrin (iv) induced acute myocardial ischemia to reverse and T-wave fall. CONCLUSION: Danshen glucose injection has a protective and therapeutic action on the experimental myocardial ischemia of rats.