Experimental study on hemocompatibility of domestic silicone-covered stent / 介入放射学杂志

ABSTRACT

Objective To evaluate the hemocompatibility of domestic silicone-covered stent in the iliac arteries of canine model. Methods Eighteen domestic stents were placed in ililac arteries of 9 adult dogs after larger ballon PTA, which included 10 silicone-covered stents and 8 bare stents for control. DSA was performed at 1,4,12 weeks after stent implantation in the iliac arteries of two groups to observe the outcomes of patency or restenosis. Animals were then euthanized isolating and stainning the stented arteries with hematoxylin and eosin for histological examination. Finally, the acute thrombosis, reendothelialization and the neointimal proliferation of both covered and bare stents were quantified on histological cross-section. Results All bare stents were patent in 12 weeks, but two silicone-covered stents were occluded at 4,12 week respectively (patent rate was 80%). Stented vascular stenosis rate was averaging 72.3% at 12 week in covered stents and 36.7% in bare stents. Conclusions The hemocompatibility of silicone-covered stents is not better than that of bare stents. Silicone appear to be inert in this experimental application.