Clinical characteristics of 379 patients with inflammatory bowel disease / 中华消化杂志

ABSTRACT

Objective To analyze the clinical characteristics of patients with inflammatory bowel disease(IBD). Methods Three hundreds and seventy-nine IBD patients identified at Sir Run Run Shaw hospital between 1994 and 2003 were studied. Demographic and clinical data were collected and analyzed. Results Of 379 patients, 317 had ulcerative colitis(UC,83.6%), 168 men, 149 women, male/female ratio 1.1∶1, mean age 44 years (range 14-79 years) and 62 had Crohn's disease(CD,16.4%), 39 men and 23 women, male/female ratio 1.7∶1, mean age 33 years (range 13-70 years).The incidence of hospitalization for IBD was 31/10 6 in 1994 and 152/10 6 in 2003. Among UC patients, 11.4% was proctitis, 25.2% was proctosigmoiditis, 18.6% was colitis of left-colon and 44.8% was pan-colitis. Seventy-one patients (22.4%) were hospitalized and 28 patients (39.4%) met the criteria for severe grade. Nine patients (2.8%) presented with arthritis, 3 patients (0.9%) presented with ophthalmologic diseases. Of 62 CD patients, 16(25.8%) had lesions restricted to the terminal ileum, 15(24.2%) had lesions involv- ing colon, 20(32.3%) had ileocolonic lesions and 11(17.7%) had lesions involving the proximal part of ileum , 33 (53.2%) patients were hospitalized and 16 patients underwent operation. Conclusions During the past 9 years, the incidence of IBD was markedly increased which was mainly contributed by UC. The characteristics of IBD were less severe and few extra-intestinal manifestations.