Comparison between efficacy of nateglinide and repaglinide in improving type 2 diabetes pancreatic ? cell function / 重庆医科大学学报

ABSTRACT

Objective:To compare the efficacy between nateglinide and repaglinide in improving type 2 diabetes pancreatic ? cell function.Methods:A double-blind,randomized clinical study was introduced to 46 patients with type 2 diabetes mellitus who were administrated with nateglinide or repaglinide for 12 weeks.Both in the 0 week and the 12th week concentration of the serum insulin,C-peptide and blood glucose,as well as plasma HbA 1c concentration,were measured respectively at preprandial 0 min and postprandial 30,60,120min.Homa-?index,insulin response to glucose(IRG)and the ratio of the area under curve between insulin and glucose(AUCi/AUCg)were computed for statistical analysis.Results:Compared with 0 week,the levels of blood glucose and plasma HbA 1c all dropped in both groups with statistical significance(P