Acute toxicity of Xidan Suspensions in mice / 重庆医科大学学报

ABSTRACT

Objective:To study acute toxicity of Xidan suspensions in mice.Methods:To measure the LD50 and to observe the response to machinery stimulation and the autonomic activity of the experimental animals when Xidan suspensions is taken orally into the mice.Results:The LD_(50) of Xidan suspensions is 148.08g(crude medicinal materials)/kg in the mice by ig.When it is taken orally(ig)into the mice at the dosage of LD_(50) or more [180g(crude medicinal materials)/kg],it is found that the response to machinery stimulation,the autonomic activity the muscle tone and the regulation of balance ability decreased obviously.Conclusion:It is indicated that Xidan suspensions could be toxic to the nervous system of mice.