Effect of Lycium Bar bar um Polysaccharide on T-lymphocyte Subsets and Dendritic Cells in H_(22)- bearing Mice / 广州中医药大学学报
Article
em Zh
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| ID: wpr-574041
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WPRO
ABSTRACT
[Objective] To investigate the effect of Lycium barbarum polysaccharide (LBP) on T-lymphocyte subsets levels, dendritic cells (DCs) counting and antigen CD80 expression in peripheral blood and tumor stroma of H22-bearing mice. [Methods] H22-bearing mice models were established. LBP in the dosages of 1.25 and 0.625 g?kg-1?d-1 was orally administered to the mice models for two weeks. The changes of T-lymphocyte subsets levels, DCs counting and antigen CDgo expression in peripheral blood and tumor stroma were detected by flow cytometry (FCM) . [ Results ] LBP increased the numbers of CD4+ and CD8+ T-cells, promoted the proliferation of CD4+ T-cells, and elevated the ratio of CD4+ /CD8+ in peripheral blood. LBP in large dosage also increased the numbers of CD4+ and CD8+ T-cells in the tumor-infiltrating lymphocytes (P
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Índice:
WPRIM
Idioma:
Zh
Revista:
Journal of Guangzhou University of Traditional Chinese Medicine
Ano de publicação:
2000
Tipo de documento:
Article