Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?
Journal of Veterinary Science
;
: 349-357, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-57412
ABSTRACT
Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute-phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, horses (n = 58) were classified as respiratory disease-free (Controls, n = 15) or with recurrent airway obstruction (RAO; n = 18), inflammatory airway disease (n = 14) or chronic interstitial pneumopathy (n = 11). There were no significant differences in fibrinogen concentrations among groups, but there was a trend toward a lower value in controls (median 0.0024 g/L) than in horses with chronic pneumopathies (median 0.0052 g/L), in particular, those with RAO (median 0.0062 g/L). Fibrinogen concentration was positively correlated with percentage of neutrophils in BALF (r(s) = 0.377, p = 0.004). SAA concentrations were low; 65.5% of samples were below the detection limit. D-dimer concentrations were also low and quantifiable concentrations were only obtained after ultrafiltration and only in RAO (median 0.1 mg/L). In conclusion, there was limited evidence of increased coagulatory activity in chronic pneumopathies, apart from RAO. It is uncertain whether fibrinogen and D-dimer concentrations increased due to their role as acute-phase proteins or as a misbalance of coagulation and fibrinolysis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteína Amiloide A Sérica
/
Fibrinogênio
/
Proteínas de Fase Aguda
/
Líquido da Lavagem Broncoalveolar
/
Ultrafiltração
/
Obstrução das Vias Respiratórias
/
Limite de Detecção
/
Fibrinólise
/
Hemostasia
/
Cavalos
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2017
Tipo de documento:
Artigo
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