Modulatory effects of prostaglandin E1 on expression of NF-?B in acute lung injury / 中华急诊医学杂志

ABSTRACT

Objective To investigate modulatory effects of prostaglancdin E1 on the expressions of NF-?B and cytokines in serum, and to explore the protection mechanisms of PGE1 in ALI.Methods Forty-five male SD rats were randomly divided into three groups: group A(normal group,n=15), group B(LPS group,n=15) and group C(LPS +lipo-PGE1 group,n=15). The pathological changes and activity of NF-?B in the lung tissue, TNF-?, IL-10 and IL-12 concentration in serum at 1 hours,2 hours and 4 hours after intraperitoneal LPS were observed.Results Hyperemia and edema of lung tissue in the LPS +lipo-PGE1 group was obviously less than that in the LPS group. Activity of NF-?B and serum concentrations of TNF-? and IL-12 in the LPS +lipo-PGE1 treated group were more decreased than that in the LPS group, and serum IL-10 concentration was obviously increased in the LPS +lipo-PGE1 group. Conclusion PGE1 reduced LPS-induced ALI through doun-regulating NF-?B activity and inhibiting expression of harmful inflammatory cytokines.