Effect of probucol on pancreatic ?-cells in STZ-induced diabetes mice / 重庆医科大学学报

ABSTRACT

Objective: To study the effect of probucol on pancreatic ?-cells in STZ-induced diabetes mice.Methods: The mice were randomly divided into four groups with ten mice in each group.The first group was given standard food(C group),The second group given standard food and 1% probucol(C+T group).The third group given standard food and treated with multiple low-dose of STZ(D group),and the forth group given standard food,1% probucol as well as treated with multiple low-dose of STZ(D+T group).The preventive intervention was undertaken with standard diet mixed with 1% probucol in Kunming mice.At different time after STZ was injected intraperitoneally,fasting blood glucose was measured.Serum insulin and glucose tolerance test was done.The pancreatic pathological changes were investigated under light microscope.Results: The fasting blood glucose at 0,1,2,3 weeks in D+C group was lower than that in D group(P