Percutaneous absorption of Rg1 in Panax notoginseng in vitro / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Artigo
em Chinês
| WPRIM
| ID: wpr-575258
ABSTRACT
AIM:
To study the percutaneous absorption of Rg1 in Panax notoginseng and the effects of some commom enhancer and pH value on it.METHODS:
Drug permeation tests were performed through excised rat skin in V-C diffusion cell.Rg1 concentration in samples was determined by HPLC.RESULTS:
Rg1 could penetrate through excised rat skin with lower permeability coefficient;in the range of concentration 300 mg/mL~60 mg/mL permeability coefficient of Rg1 decreased as its concentration increasd;Among enhancers,10% ethanol,10%,20% and 30% propylene glycol,2% Azone,2% Eucalyptus Oil and 5% Oleic Acid had markedly promotive effect on transdermal penetration of Rg1.CONCLUSION:
The research will provide experimental data for skin administration of Chinese medicine containing Panax notoginseng.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional Patent Medicine
Ano de publicação:
1992
Tipo de documento:
Artigo
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