Clinicopathologic features of sporadic colorectal cancers with CpG island methylator phenotype / 中华消化杂志

ABSTRACT

Objective To investigate the clinicopathologic features of sporadic colorectal cancers with CpG island methylator phenotype. Methods The methylation of the promotors of the five genes including p14, hMLH1, p16, MGMT and MINT1 were detected using methylation specific PCR in 71 patients to determine the clinicopathologic characteristics of sporadic colorectal cancers with CpG island methylator phenotype. Results Fifteen out of 71 (21. 1%) patients were positive for the CpG island methylator phenotype. The proportion of the right-sided colonic cancers(40. 0% vs. 12. 5% , P