Pharmacokinetics of ephedrine gels and extractum ephedrae gels in guinea pig / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Artigo
em Chinês
| WPRIM
| ID: wpr-575550
ABSTRACT
AIM:
To establish a method to determine the serum concentration of ephedrine,and to study its pharmacokinefics in guinea pig.METHODS:
The serum concentration of ephedrine gels transdermal administration in guinea pig were determined by HPLC and pharmacokinetic parameters were calculated by computer.(RESULTS:
)The calibration curve was linear in the range of 0.5~2 ?g with r=0.998 0.The limit of identification was 0.02 ?g/mL.The pharmacokinetics behavior of ephedrine showed one order absorption.The main parameters after adminstrition of ephedrine gels and extractum ephedrae gels were as followst_(1/2)k_a were 1.362 1 and(l.541 8),t_(1/2)k_e were 2.627 4 and 3.262 2 h,T_(max) were 3.124 3 and 3.440 9 h,C_(max) were 0.115 6 and 0.081 0 ?g/mL,AUC were(0.081 0) and 0.741 5 ?g?h/mL.CONCLUSION:
Ephedrine shows a fast rate of absorption in guinea pig,serum concentration of ephedrine is stable and lasting potency,and indicates the reason of transdennal administration of Herba Ephedrae preparation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional Patent Medicine
Ano de publicação:
1992
Tipo de documento:
Artigo
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