Effect of Shuxuening Injection on NO, NOS, SOD and MDA of Angina Pectoris Patients / 中国中医药信息杂志

ABSTRACT

Objective To observe the effect of Shuxuening Injection NO, NOS, SOD and MDA on of angina pectoris patients. Methods 100 patients with angina pectoris were randomly divided into two groups. 50 patients in treatment group were treated with Shuxuening Injection, 5 mL once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), one time a day. 50 patients in control group were treated with isosorbide mononitrate injection, 60 mg once, drop into 250 mL 5% glucose injection (it change into 250 mL 0.9% sodium chloride injection if the patient have diabetes), 15 gtt one minute, one time a day. Results NO, NOS and SOD of the treatment group were objective improved, and MDA objective reduced. NO improved from (47.61?8.76)?mol/L to (71.84? 13.26)?mol/L, NOS improved from (1.64?0.23)U/mL to (2.31?0.29)U/mL, SOD improved from (46.34? 5.62)U/mL to (64.54?9.10)U/mL, and MDA reduced from (8.96?1.76)U/mL to (6.71?1.43)U/mL. Total effective rate in improving angina pectoris was 96%, and ECG was 76%. The time (ischemic ST-T changes) of holter ECG was reduced from (130.45?18.61)min to (32.33?5.32)min, there was a significant difference between the two groups (P