The effect of hyaluronic acid on anti-inflammatory action in mouse
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 16-22, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-57599
ABSTRACT
PURPOSE:
The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL ANDMETHODS:
Mice of this study were devided into 4 groups Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).RESULTS:
Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.CONCLUSION:
It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA Mensageiro
/
Dinoprostona
/
Expressão Gênica
/
Citocinas
/
Orelha
/
Edema
/
Elétrons
/
Ácido Hialurônico
/
Inflamação
/
Luz
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2010
Tipo de documento:
Artigo
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