Effect of Wenpishen Nuanganwei Recipes on Insulin Resistance and Low Rank Inflammation in Patients with Type 2 Diabetes Mellitus / 中药新药与临床药理

ABSTRACT

Objective To observe the effect of Wenpishen Nuanganwei Recipes(WPSNGWR)on insulin resistance(IR)and low rank inflammation in patients with type 2 diabetes mellitus(T2DM).Method 80 patients with T2DM were selected and randomly divided into the treatment group(n=40)and the control group(n=40).Patients attended to the education courses for diabetes and were treated with hypoglycemic agent in routine and reasonable diet.To those patients in the treatment group,WPSNGWR decoction was given additionally with one dose taken twice per day,a treatment course for a month,totally for 2 courses.Parameters as fasting blood glucose(FBG),postprandial 2 hours blood glucose(P2HBG),fasting insulin(FINS),C-reactive protein(CRP)before and after treatment were measured,and insulin sensitive index(ISI)was calculated.Results After 2 months of treatment,the serum level of FBG and P2HBG lowered in both groups(P