Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia / 대한해부학회지
Anatomy & Cell Biology
;
: 183-190, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-57790
ABSTRACT
Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sais de Tetrazólio
/
Encéfalo
/
Medicamentos de Ervas Chinesas
/
Fatores de Risco
/
Amarelo de Eosina-(YS)
/
Fármacos Neuroprotetores
/
Acidente Vascular Cerebral
/
Infarto Encefálico
/
Hipóxia-Isquemia Encefálica
/
Salvia miltiorrhiza
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2013
Tipo de documento:
Artigo
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