Effect of GETO on Learning and Memory of Sporadic Alzheimer’s Disease Rats / 中国中医药信息杂志

ABSTRACT

Objective To establish rat models with Sporadic Alzheimer’s disease(SAD) induced by intracerebroventricular administration of streptozotocin(ic-STZ),and observe the effects of compound Jinsiwei(GETO) on learning and memorizing ability of rats.Methods To establish the Sporadic Alzheimer’s disease model by intracerebroventricular micro-injection of STZ bilaterally.GETO groups were treated with gastric perfusion of GETO in three different dosage for 3 months.Learning and memorizing ability of the rats were inspected through Morris water maze test.The effects of GETO and Donepezil were observed and compared.Results In place navigation test,the escape latency and swimming distance were significantly longer in the model group than that in the sham group(P