Effects of Digoxin on Cardioventricular Function in Rats after Simulated Weightlessness / 航天医学与医学工程
Space Medicine & Medical Engineering
; (6)2006.
Article
em Zh
| WPRIM
| ID: wpr-577986
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the protective effects of Digoxin on cardioventricular function in rats after simulated weightlessness.Methods Eighty rats were divided randomly into 5 groups:control(Con)group,tail-suspended+sham feeding(TS+SF)group,tail-suspended+Digoxin 2 wk(TS+D2)group and tail-suspended+Digoxin 3 wk(TS+D3)group.The TS+SF group was given the distilled water.At the end of tail-suspended for 3 weeks,the heart function of 10 rats in each group was examined with echocardiography.The level of atrial natriuretic polypeptide(ANP)in serum was measured with immunoradiometric assay in other 6 rats.Results Compared with TS+SF group,the contractile function of LV improved in TS+D2 and TS+D3 groups(P0.05).Conclusion Digoxin can improve muscle contractile and blood ejection of LV and retard the tendency of atrophy in simulated weightlessness.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Space Medicine & Medical Engineering
Ano de publicação:
2006
Tipo de documento:
Article