Controlled hypotension with remifentanil and isoflurane in endovascular treatment of intracranial aneurysms / 重庆医科大学学报

ABSTRACT

Objective:To investigate the clinical efficacy of deliberate hypotension with remifentanil in endovascular treatment of intracranial aneurysms.Methods:A total of 30 cases of intracranial aneurysms,were divided according to the condition of combined with hypertension,into control group(Group C) and hypertension group(Group H),each with 15 cases.Two groups adopted induction of anesthesia in patients with intravenous propofol 1.5～2mg/kg,remifentanil 1?g/kg,vecuronium 0.1mg/kg.Maintenance of anesthesiapropofol 3~5mg/(kg?h) and remifentanil 0.2～0.4?g/(kg?min),and intermittent intravenous injection of vecuronium 0.06mg/kg maintained muscle relaxation.When controlled hypotension was needed,the infusion of remifentanil to accelerated 0.8?g/(kg?min).Heart rate and blood pressure were recorded at baseline,after anesthesia induction,on tracheal intubation,before intracranial aneurysm embolism,after intracranial aneurysm embolism and extubation.Results:After induction of anesthesia,there were obvious decline in blood pressure and heart rate in both group(P