The expression of RGMa and RhoA in the hippocampus of rats with cognitive impairment induced by A? / 重庆医科大学学报

ABSTRACT

Objective:To observe the expression of RGMa and RhoA in the hippocampus of cognitive impairment rats induced by A?1-40. Methods:Morris water maze was used to study the cognitive function, and reverse transcription-polymerase chain reaction(RT-PCR)method was used to determine the changes of RGMa mRNA and RhoA mRNA expressions. mmunohistochemistry was used to detect the expression of RGMa protein. Results:Model group showed learning and memory impairment, the expression levels of RGMa mRNA and protein in the hippocampus decreased compared with control group(p