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Improving pancreas targeting capability of hydroxycamptothecin using lipid emulsion as drug carrier / 中草药
Chinese Traditional and Herbal Drugs ; (24)1994.
Artigo em Chinês | WPRIM | ID: wpr-578214
ABSTRACT
Objective To investigate the effect of lipid emulsion as drug carrier on pancreas targeting capability of hydroxycamptothecin. Methods Hydroxycamptothecin-loaded lipid emulsion was prepared by a two-step emulsifying process with soybean phospholipid and soybean oil as main excipients. Hydroxycamptothecin-loaded lipid emulsion and hydroxycamtothecin injection were iv administrated to rabbits at a single dose of 3.5 mg/kg. The hydroxycamptothecin concentration in the pancreas was determined by HPLC with camptothecin as the internal standard. Results The HPLC method for the determination of hydroxycamptothecin and camptothecin was sensitive and accurate. The hydroxycamptothecin concentration in the pancreas was greatly improved in hydroxycamptothecin-loaded lipid emusion compared with hydroxycamtothecin injection. Conclusion The pancreatic gland targeting capability is greatly improved, when lipid emulsion is used as drug carrier.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Traditional and Herbal Drugs Ano de publicação: 1994 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Traditional and Herbal Drugs Ano de publicação: 1994 Tipo de documento: Artigo