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A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy
Journal of the Korean Pediatric Society ; : 1430-1432, 1998.
Artigo em Coreano | WPRIM | ID: wpr-57831
ABSTRACT
Inappropriate secretion of antidiuretic hormone (ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering the osmotic threshold for vasopressin release induces SIADH in humans. In our case, the patient did not receive cis-platinum during chemotherapy. From this we concluded that vinblastine alone can induce SIADH without nephrotoxicity of cis-platinum. We experienced a case of inappropriate ADH secretion secondary to vinblastine therapy in a 5- month-old male infant who has been taking vinblastine due to Langerhans cell histiocytosis. We report this case with a brief review of related literatures.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vimblastina / Vincristina / Bleomicina / Vasopressinas / Histiocitose de Células de Langerhans / Cisplatino / Tratamento Farmacológico / Alcaloides / Síndrome de Secreção Inadequada de HAD Limite: Humanos / Lactente / Masculino Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vimblastina / Vincristina / Bleomicina / Vasopressinas / Histiocitose de Células de Langerhans / Cisplatino / Tratamento Farmacológico / Alcaloides / Síndrome de Secreção Inadequada de HAD Limite: Humanos / Lactente / Masculino Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 1998 Tipo de documento: Artigo