Preparation of curcumin solid lipid nanoparticles by film-ultrasonic method / 中成药
Chinese Traditional Patent Medicine
;
(12)1992.
Artigo
em Chinês
| WPRIM
| ID: wpr-578388
ABSTRACT
AIM:
To optimize technique for preparing curcumin solid lipid nanoparticles by film-ultrasonic dispersion.METHODS:
The influence of various factors,including the consumption of curcumin,stearic acid,lecithin and tween-80,and their effects on the entrapment efficiency and the ratio of loading drug were investigated.And the optimum formula was selected through uniform design test.RESULTS:
Under the condition of 30 mg of curcumin,60 mg of lecithin,117 mg of stearic acid and 10 mL of tween-80(1.0%) curcumin solid lipid nanoparticals had good size distributions.The mean particle size diameter was 58.0 nm and the average entrapment efficiency and the ratio of loading drug approached 95.98% and 15.87%,respectively.CONCLUSION:
The technique for preparing curcumin solid lipid nanoparticals N by film ultrasonic method is feasible.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional Patent Medicine
Ano de publicação:
1992
Tipo de documento:
Artigo
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