Synergistic induction of apoptosis of HEP-2 cell line by the combination of TRAIL and 5-FU,DDP / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-578550
ABSTRACT
Objective:
To investigate whether TRAIL can synergize 5-Fu and DDP to kill HEP-2 cell line.Methods:
MTT was used to detecet the cytotoxicity of HEP-2 cell line intervented in 5-FU,DDP,TRAIL,5-FU+TRAIL and DDP+TRAIL.Fluorescence microscope and FCM were used to detecet the apoptosis rate of cell.Results:
HEP-2 cell line was insensitive in TRAIL,but the apoptosis rate obviously was upgraded after intervented in 5-FU+TRAIL and DDP+TRAIL.Conclusion:
TRAIL in combination with subtoxic dose of 5-FU and DDP can effectively kill HEP-2 cell line.The combination of TRAIL,5-FU and DDP induced apoptosis of HEP-2 cell line.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chongqing Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
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