Serum Pharmacochemistry and Pharmarcokinetics Study of Naoxuening Injection / 中药新药与临床药理

ABSTRACT

Objective To study the serum pharmacochemistry and pharmacokinetics of Naoxuening Injection(NXI).Methods Based on the established HPLC fingerprint of NXI,analysis and comparison were carried out among the HPLC profiles of NXI,blank plasma and human serum samples obtained after intravenous administration of NXI.and the main compounds were identified and then the pharmacokinetics of the main compounds were studied.Results Three compounds were i- dentified from the serum after intravenous administration of NXI.Two were the compounds containing in NXI,which were named after geniposide and paeonol,respectively.The other one was identified as metabolic product.The concentration- time curve of geniposide in blood accorded with one-compartment model of pharmacokinetics,and 70 % of geniposie was cleared from the kidney.The concentration-time curve of paenol in blood accorded with two - compartment model of pharmacoki- netics,and 0.04 % of geniposie was cleared from the kidney.Conclusion The compounds contained in the blood and their metabolites are the effective constituents,and the further serum pharmacochemical research will be beneficial to the pharmacol- ogy and the therapeutic mechanism of of NXI.