Effects and Mechanisms of Ursolic Acid on Inducing Apoptosis of Human Esophageal Carcinoma Cell Line Eca-109 / 中药新药与临床药理
Traditional Chinese Drug Research & Clinical Pharmacology
;
(6)2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-578861
ABSTRACT
Objective To investigate the effects and possible mechanisms of ursolic acid (UA) on inhibiting proliferation of human esophageal carcinoma cell Eca-109 and inducing its apoptosis. Methods Cell proliferation was determined by MTT assay. Electron microscope was used to observe the ultrastructural changes of Eca-l09 induced by UA. Cell cycle and apoptotic rate were analyzed by flow cytometry (FCM),and the expression of P27kip1,Bcl-2 and Bax were detected by Western blot method. Results UA could significantly inhibit the growth of Eca-109 cells(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Traditional Chinese Drug Research & Clinical Pharmacology
Ano de publicação:
2000
Tipo de documento:
Artigo
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