Effect of Spleen-strengthening and Qi-invigorating Prescription on Serum Inflammatory Factor in Type 2 Diabetes Mellitus Rats with Spleen-Qi Deficiency Syndrome / 中药新药与临床药理

ABSTRACT

Objective To observe the effect of spleen-strengthening and qi-invigorating prescription(SQP) on serum inflammatory mediators in type 2 diabetes mellitus rats with spleen-qi deficiency syndrome. Methods Rat models were induced by intraperitioneal injection of streptozocin(STZ,30 mg/kg) combined with overstrain,abnormal meals,and greasy foods. Model rats were randomly allocated to three groupsmodel group was treated with purified water; western medicine(WM) group was treated with aspirin enteric-coated tablet,and traditional Chinese medicine(TCM) group was treated with SQP. And the normal rats were allocated to the normal control group. The course of treatment lasted 6 weeks.Parameters such as fasting blood glucose(FBG),fasting insulin(FINS),C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-?(TNF-? ) were measured after treatment,and insulin sensitive index(ISI) was also calculated. Result After treatment for 4 weeks,the above observation indexes were higher in model group than those in the normal control group. In TCM group,the serum levels of FBG,FINS,CRP,IL-6,and TNF-? were significantly lowered,while ISI was increased,and the effect being better than that in the WM group(P