A comparison of premixed insulin aspart 30 and premixed human insulin 30R in treatment of type 2 diabetes / 重庆医科大学学报

ABSTRACT

Objective:To compare the safety and efficacy of premixed insulin aspart 30 (BIAsp30) with premixed human insulin 30R (BHI30)used in twice-daily injection regimen in patients with type 2 diabetes. Methods:Sixty-eight patients with inadequate glycemia control by oral drug were randomly divided into two groups using twice-daily insulin for 12 weeks comparison of BIAsp30 and BHI30. We compared HbA1c,seven-point blood glucose and frequency of hypoglycemia in two groups. Results:Blood glucose after breakfast and after dinner were significantly lower in BIAsp30 group than in BHI30 group(P0.05),meanwhile no serious hypoglycemia happened in BIAsp30 group. Conclusion:Post-prandial glycemia control was significantly improved,without increasing the risk of hypoglycemia,when people with type 2 diabetes were treated in twice-daily injection regimen with BIAsp30,as compared with BHI30.