Immunohistochemical Study of beta-catenin Expression between Hepatocellular Carcinoma and Cholangiocarcinoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 117-121, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-57942
ABSTRACT
PURPOSE:
beta-catenin is an intracellular protein that is an integral component of the cadherin-mediated cell-cell interaction and a downstream transcriptional activator in the wnt signal transduction pathway. Inappropriate activation of beta-catenin has recently been implicated in the development of hepatocellular carcinoma and cholangiocarcinoma. Nuclear beta-catenin expression is strongly associated with gene mutation. This study was designed to evaluate the pattern of beta-catenin expression between hepatocellular carcinoma and cholangiocarcinoma. MATERIALS ANDMETHODS:
Immunohistochemical expression of beta-catenin was studied in 7 normal livers, 33 hepatocellular carcinomas and 20 cholangiocarcinomas, that were formalin fixed and paraffin embedded.RESULTS:
beta-catenin was expressed mainly in the cytoplasmic membrane of the normal hepatocytes and bile ducts. Nuclear expressions, not noted in the normal liver, were noted in 30% of the hepatocellular carcinomas and 10% of the cholangiocarcinomas. And, nuclear expression was more common in the high grade (50%) hepatocellular carcinomas than the low grade (18%) hepatocellular carcinomas (p<=0.05).CONCLUSION:
The above results indicate that nuclear expression of beta-catenin is observed in the carcinoma but not the normal liver, and is associated with high grade liver carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parafina
/
Ductos Biliares
/
Transdução de Sinais
/
Membrana Celular
/
Colangiocarcinoma
/
Carcinoma Hepatocelular
/
Hepatócitos
/
Beta Catenina
/
Formaldeído
/
Fígado
Idioma:
Coreano
Revista:
Cancer Research and Treatment
Ano de publicação:
2002
Tipo de documento:
Artigo
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