Study on the dynamic distribution of [~(14)C]benzo(a)pyrene in the corpus striatum / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2003.
Artigo
em Chinês
| WPRIM
| ID: wpr-579797
ABSTRACT
Objective:
To study the dynamic distribution of BaP in the corpus striatum by r-counting and light microscopic autoradiography,then to explore the neurotoxic mechanism of BaP.Methods:
100 SD male rats were divided into control group(n=40)and test group(n=60),experimental animals were given a single intravenous injection of 3.7?105 Bq/kg of 14CBaP while the same doses of Normal Saline were given to the control group.The rats were sacrificed at 1h,1 d,2 d,3 d and 7 d after the administration of radiolabelled BaP.During the experiment,some toxicological symptoms were observed and the ratios of brain-weight/body-weight were detected.Light microscopic autoradiography and r-counting were used to observe the dynamic distribution of BaP in the corpus striatum.Results:
The change of toxicological symptoms are observed and the decrease ratios of brain-weight/body-weight are detected.R-counting shows that the percentage dose/g of 14CBaP in striatum is significant higher than in hippocampus and cortex at 1d and 2 d after administration.Light microscopic autoradiography shows that the silver granules in striatum reach the peak in 1d and sharp decrease in 2 d,which can be found even at 7d.Conclusion:
BaP can penetrate the blood-brain barrier and distribute in corpus striatum,inducing CNS toxicity in SD rat.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chongqing Medical University
Ano de publicação:
2003
Tipo de documento:
Artigo
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