Expression of ?-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis / 重庆医科大学学报

ABSTRACT

Objective:To investigate the expression of ?-caten in and focal adhesion kinase(FAK)in colon carcinoma and to reveal their correlation with tumor clinicopathological features. Methods:The expression of ?-catenin and FAK in tumor tissue and normal tissue of 34 colon carcinoma patients were detected by immunohistochemistry and Western blot.Results:The expression of ?-catenin and FAK were detected both in tumor tissue and normal tissue,mostly in plasmalemma and endochylema.The expression of ?-catenin was significantly lower in tumor tissue than that in normal tissue(t=10.693,P