The effects of Shenfu injection on brain injury in patients undergoing valve replacement / 重庆医科大学学报

ABSTRACT

Objective:To investigate the effects of Shenfu injection on cerebral oxygen balance and cerebral ischemia-reperfusion injury in patients undergoing valve replacement during cardiopulmonary bypass,in order to Explore its efficacy and find reasonable route of administration. Methods: 32 patients undergoing valve replacement,aged 25～54,with the heart function of 2～3 level,were randomly divided into four groups with eight in each. Patients in group E1 received SFI 1.5 ml/kg before blocking of the aorta;Patients in group E2 received SFI 1.5 ml/kg after opening of the aorta;Patients in group E3received SFI 0.75 ml/kg before blocking and after opening the aorta,too. Patients in group C received 0.9% NaCl. Blood samples were taken from internal jugular vein and arteria radialis after trachea cannula(T1),10 min after CPB(T2),cooling stability stage(T3),recovery temperature to 33℃(T4),the end of CPB(T5) and 1 hour after the end of CPB(T6)for blood gas analysis.Then,Plasma S100? protein concentration、MDA、Glu and the activity of SOD in jugular vein bulb were determined. Results: The CERO2,SjvO2 changes in Group E1,E2,E3 were stable,moreover,SjvO2 was significantly higher than that in group C (P 0.05),In group E3,SOD had the highest activity at T6(P