The therapeutic effects comparison between plasma exchange and hemoperfusion in treating pattents of thronic hepatitis with hyperbilirubinemia / 重庆医科大学学报

ABSTRACT

Objective:To observe and compare the efficacy,safety and turnover of plasma exchange and hemoperfusion in treating patients of chronic hepatitis with hyperbilirubinemia.Methods:This is a retrospective study.85 patients with hyperbilirubinemia were treated with plasma exchange and 68 patients with hyperbilirubinemia were treated with hemoperfusion.The clinical symptoms,liver function,bilirubin and prothrombin time activity were compared before and after the treatment in one group,and between the two treatment groups,were examined.Adverse effects were observed in the same time.Results:After plasma exchange,bilirubin decreased significantly;prothrombin time activity and albumin increased significantly(541.68?186.94 VS 337.65?130.52,40.50?19.32 VS 55.29?19.45,30.12?4.24 VS 34.57?3.17).After hemoperfusion,bilirubin decreased;prothrombin time activity and albumin decreased but not significantly(482.69?189.36 VS 473.58?183.57,41.63?19.85 VS 43.03?20.85,30.86?4.31 VS 30.26?3.48).Compared with hemoperfusion,bilirubin,prothrombin time activity and albumin in plasma exchange had more significant change(204.03?102.04 VS 9.11?87.46,-14.79?16.20 VS -1.40?12.78,-1.45?20.83 VS 0.60?3.58,P