Effect of Shuxuetong injection on the expressions of TGF-?_1 and Col-IV in renal tissues in diabetic rats / 重庆医科大学学报
Journal of Chongqing Medical University
;
(12)2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-580353
ABSTRACT
Objective:
To investigate the effect of Shuxuetong injection on the urine protein excretion changes and expressions of transforming growth factor ?(1TGF-?1)and collegen type Ⅳ(Col-Ⅳ)in renal tissues in diabetic rats.Methods:
Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin(STZ).Rats were randomly divided into control group,untreated DN group,Shuxuetong group and Benazepril group.Urinary albumin excretion rate(UAER),?2-microglobulin(?2-MA)and KW/BW(kidney weight/body weigh)were determined 8 weeks later.The expressions of TGF-?1 and Col-Ⅳ in renal tissues were determined by using immunohistochemical methods.Results:
After interference,compared with the untreated DN group,UAER,?2-MA,KW/BW in the Shuxuetong group were significantly down-regulated(P
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chongqing Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS