Alteration of the expression of PTEN in rats with aging / 重庆医科大学学报

ABSTRACT

Objective:To investigate the alteration of the expression of PTENin rats with aging.Methods:Wistar rats were divided into 3 groups3-month-old group,12-month-old group and 24-month-old group(n=6).Immunohistochemistry of CD34 was employed to detecte angiogenesis in the kidneys with aging.The protein expression of PTEN was examined by Western Blot.Immunohistochemistry was also employed to detect the expression of PTEN in the kidneys with aging.Results:(1)Compared with 3-month-old rats and 12-month-old rats,the level of PTEN protein expression in kidneys of 24-month-old rats was higher than that of 3-month-old rats and 12month-old rats,as examined by Western Blot(P