Study of association between ApoB/ApoA1 ratio and insulin resistance / 重庆医科大学学报

ABSTRACT

Objective:To assess if the ratio of ApoB/ApoA1 is related to insulin resistance.Methods:673 adults living in Chongqing were enrolled.Weight,height,blood pressure,waist circumferences,fasting plasma glucose(FPG),fasting serum insulin(FINS)and lipids were measured.ApoB/ApoA1 ratio,BMI and insulin resistance index(Homa-IR)were calculated.Subjects were divided into four groups according to the quartiles of ApoB/ApoA1 ratio.Logistic regression was used to estimate the relation between ApoB/ApoA1 ratio and insulin resistance.Results:Compared with the non-insulin resistant group,the insulin resistant group is older and has on average greater mean values for BMI,systolic and diastolic blood pressure,fasting plasma glucose,triglycerides,LDL-cholesterol,and ApoB/ApoA1 ratio.In contrast,insulin resistant subjects has significantly lower HDL-cholesterol than insulin sensitive subjects(P