An analysis on the relationship between polymrhism of intron 2 in serotonin transporter and polymrhism of serotonin transporter gene and attempted suicide / 重庆医科大学学报

ABSTRACT

Objective:To explore the association between attempted suicide and polymrhism of intron 2 in serotonin transporter and polymrhism of serotonin transporter(5-HTTLPR).Methods:Using the technique of polymerase chain reaction(PCR),the variable number of tandem repeat polymorphism(5-HTTVNTR)and 5-HTTLPR was determined in 71 patients with attempted suicide subjects and 80 control subjects.The allelic and genetypes distributions in two groups were compared.Results:There were no significant differences in intron 2-VNTR genotype and allele frequency distributions between attempted suicide and healthy control subjects(?2= 1.08,P=0.58;?2=0.99,P=0.32).The frequencies of allele S were significantly higher in suicides attempted suicide patients with psychiatric disorder(85.1%)than in normal controls(72.5%)and suicides without psychiatric disorde(r69.1%)(?2=4.49,P=0.04;?2=5.21,P=0.03).Conclusion:The results suggested that the polymrhism of intron 2 of 5-HTT gene no associated with attempted suicide in the Han nationality.But the presence of 5-HTTLPR alleles S may increase the risk for attempted suicide.